The Gunners will travel north to Merseyside looking to at least maintain their two-point advantage over Manchester City and Chelsea following the latter’s 1-0 win over the former on Monday.
If Wilshere is available, it will be especially welcome news for Arsenal given Mathieu Flamini is suspended while both Aaron Ramsey and deadline day loan signing Kim Kallstrom are injured.
“We might have Wilshere back and that’s basically it. (Mikel) Arteta is all right,” Wenger said.
“It’s important to have as many players back as possible in the squad,” the Frenchman added.
“In the big games it’s always decided by having the complete squad available.”
Saturday’s match will see Arsenal up against in-form Liverpool striker Luis Suarez – a player they tried but ultimately failed to lure to north London with a bid of £40 million.
Uruguay international Suarez has since scored 23 Premier League goals for Liverpool and signed a new contract with the Reds.
But Wenger insisted he’s no regrets in trying to bring Suarez to Liverpool.
“He was never our player. It’s just a situation that did not come off and that is it.
“For us the important thing is to win the game. What happened in the summer has nothing to do with that.
“If you want to win the game then what is for sure is, he is one of the players you have to keep quiet.”